Description

Rac-Lasofoxifene is a selective estrogen receptor modulator (SERM) compound, representing a critical intermediate and reference standard in pharmaceutical research and development. Its primary value lies in its utility for studying the structure-activity relationships of SERMs, particularly in the development of treatments for osteoporosis and breast cancer. This compound is essential for research institutions, pharmaceutical R&D departments, and analytical laboratories focused on endocrine therapy and drug discovery.

Application

• Pharmaceutical reference standard for analytical method development and validation.
• Key intermediate in the research and synthesis of novel Selective Estrogen Receptor Modulators (SERMs).
• Biochemical research tool for studying estrogen receptor binding and modulation mechanisms.
• Preclinical studies investigating potential therapeutic applications for bone density and oncology.
• Impurity standard for quality control in the manufacturing of related active pharmaceutical ingredients (APIs).
• Metabolite studies and pharmacokinetic research related to SERM compounds.

Basic Information

Product Name	Rac-Lasofoxifene
CAS No.	180915-78-0
Molecular Formula	C₂₈H₃₁NO₂
Molecular Weight	413.55 g/mol
Synonyms	(±)-Lasofoxifene; Racemic Lasofoxifene; CP-336,156; 5,6,7,8-Tetrahydro-6-phenyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1-naphthalenol; Fablyn (racemic form); 1-Naphthalenol, 5,6,7,8-tetrahydro-6-phenyl-2-[4-(2-(1-pyrrolidinyl)ethoxy)phenyl]-
EINECS	Contact for details

Quality Control

Our Rac-Lasofoxifene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed results to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.