Description

(S,E)-Ethyl 3-(1-Hydroxypropan-2-Ylamino)Acrylate is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. Its defined stereochemistry and functional group array make it a critical precursor for constructing complex molecules with high enantiomeric purity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel APIs, especially in antiviral, anticancer, and neurological drug discovery programs.
• Agrochemical Synthesis: Used in the development of enantiomerically pure pesticides and herbicides, where specific stereochemistry is crucial for bioactivity.
• Asymmetric Catalysis Research: Serves as a model substrate or ligand precursor in the development of new asymmetric synthetic methodologies.
• Fine Chemical Production: Employed in the multi-step synthesis of complex natural products, flavors, and fragrances requiring precise stereocontrol.
• Peptidomimetic Chemistry: The hydroxyamino acrylate structure is valuable for creating non-natural amino acid analogs and peptide backbone modifications.

Basic Information

Product Name	(S,E)-Ethyl 3-(1-Hydroxypropan-2-Ylamino)Acrylate
CAS No.	180682-82-0
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	Ethyl (2S,3E)-3-[(2S)-1-hydroxypropan-2-ylamino]prop-2-enoate; (S,E)-Ethyl 3-[(S)-1-Hydroxy-2-propylamino]acrylate; (S,E)-Ethyl 3-((S)-1-Hydroxypropan-2-ylamino)acrylate; Ethyl (S,E)-3-((S)-1-hydroxypropan-2-ylamino)acrylate; (S,E)-Ethyl β-[(S)-1-Hydroxy-2-propylamino]acrylate; A chiral β-aminoacrylate ester; (S)-1-Hydroxypropan-2-amine acrylate derivative
EINECS	Contact for details

Quality Control

Our (S,E)-Ethyl 3-(1-Hydroxypropan-2-Ylamino)Acrylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including chiral HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.