Description

1'-n-Boc-1,2-Dihydro-1'H-Spiro[Indole-3,4'-Piperidine] is a high-value, protected spirocyclic indole derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in providing a versatile and reactive scaffold for constructing complex nitrogen-containing heterocycles, which are central to pharmaceutical discovery. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on developing novel active ingredients for therapeutic and crop protection applications.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Spirocyclic Scaffold Development: Used to construct complex spirocyclic frameworks that are highly sought after in drug design for their three-dimensionality and potential to improve drug-like properties.
• Indole and Piperidine Chemistry: Facilitates the exploration of structure-activity relationships (SAR) around the indole-piperidine pharmacophore, a common motif in bioactive molecules.
• Agrochemical Research: Employed in the synthesis of novel compounds for crop protection and pest management research.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study biological pathways and protein functions.
• Academic & Contract Research: A valuable reagent for universities and contract research organizations (CROs) conducting advanced synthetic methodology and heterocyclic chemistry research.

Basic Information

Product Name	1'-n-Boc-1,2-Dihydro-1'H-Spiro[Indole-3,4'-Piperidine]
CAS No.	180465-84-3
Molecular Formula	C17H22N2O2
Molecular Weight	286.37 g/mol
Synonyms	1,2-Dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 1'-Boc-1,2-dihydrospiro[indole-3,4'-piperidine]; 1'-Boc-spiro[indoline-3,4'-piperidine]; Spiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1'-N-Boc-1,2-dihydrospiro[indole-3,4'-piperidine]; BOC-Spiroindolepiperidine; 180465-84-3
EINECS	Contact for details

Quality Control

Our 1'-n-Boc-1,2-Dihydro-1'H-Spiro[Indole-3,4'-Piperidine] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the high standards required for research and development applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.