Description

Proline, 4-Hydroxy-5-Oxo-, Methyl Ester, trans- (9Ci) is a specialized proline derivative, a key chiral building block and intermediate in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of pharmaceuticals and bioactive compounds. It is needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used in the design and construction of peptide analogs and constrained peptides to study biological activity and improve metabolic stability.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or catalysts used in enantioselective transformations.
• Agrochemical Synthesis: An intermediate in the production of advanced, biologically active compounds for crop protection.
• Fine Chemical Production: Employed in the multistep synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and for exploring new reaction pathways in laboratory settings.

Basic Information

Product Name	Proline, 4-Hydroxy-5-Oxo-, Methyl Ester, trans- (9Ci)
CAS No.	180321-18-0
Molecular Formula	C7H9NO4
Molecular Weight	171.15 g/mol
Synonyms	trans-4-Hydroxy-5-oxoproline methyl ester; Methyl (2S,4R)-4-hydroxy-5-oxopyrrolidine-2-carboxylate; (2S,4R)-4-Hydroxy-5-oxo-1-pyrrolidinecarboxylic acid methyl ester; 4-Hydroxy-5-oxo-L-proline methyl ester; L-trans-4-Hydroxy-5-oxoproline methyl ester; 5-Oxo-4-hydroxyproline methyl ester; Methyl 4-hydroxy-5-oxoproline
EINECS	Contact for details

Quality Control

Our Proline, 4-Hydroxy-5-Oxo-, Methyl Ester, trans- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.