Description

Spiro[Isochroman-1,4'-Piperidine] CAS NO 180160-97-8 is a high-purity spirocyclic organic compound featuring a unique fused isochroman-piperidine structure, making it a valuable and versatile chemical intermediate. Its rigid, three-dimensional architecture is crucial for imparting specific biological activity and modifying physicochemical properties in advanced molecular design. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, particularly for central nervous system (CNS) targets, due to its spirocyclic scaffold which can enhance blood-brain barrier penetration and receptor binding affinity.
• Agrochemical Research: Used in developing novel pesticides and herbicides, where its complex structure can contribute to new modes of action and improved environmental profiles.
• Material Science Precursor: Serves as a sophisticated monomer or ligand precursor for advanced polymers, catalysts, or metal-organic frameworks (MOFs) requiring specific steric and electronic properties.
• Academic & Contract Research: Essential for medicinal chemistry programs in universities and CROs (Contract Research Organizations) focused on heterocyclic and fragment-based drug discovery.
• Chemical Library Synthesis: Employed in the generation of diverse screening libraries for high-throughput testing against various biological targets.

Basic Information

Product Name	Spiro[Isochroman-1,4'-Piperidine]
CAS No.	180160-97-8
Molecular Formula	C13H15NO
Molecular Weight	201.27 g/mol
Synonyms	1',4'-Dihydrospiro[isochromene-1,4'-piperidine]; Spiro[1H-isochromene-1,4'-piperidine]; 1,4-Dihydrospiro[isochromene-1,4'-piperidine]; 1,4-Dihydro-1,4'-spiro[2]benzopyran-1,4'-piperidine; 1,4-Dihydrospiro[isochromene-1,4'-piperidine]; Spiro(isochroman-1,4'-piperidine); 1,4-Dihydrospiro[isochromene-1,4'-piperidine]
EINECS	Contact for details

Quality Control

Our Spiro[Isochroman-1,4'-Piperidine] is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.