Description

6-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidine] is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic molecular architecture. This compound is of significant commercial importance for its role as a key building block in the synthesis of complex bioactive molecules, particularly in central nervous system (CNS) drug discovery. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in developing novel therapeutic agents, where precise chemical structure and reliable purity are paramount.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel pharmacophores.
• CNS Drug Development: Serves as a core scaffold for molecules designed to interact with specific receptors in the central nervous system.
• Chemical Synthesis Building Block: Employed in organic synthesis to construct complex heterocyclic systems due to its reactive chloro and spirocyclic groups.
• Process Chemistry & Scale-Up: Supplied for route scouting and process optimization from milligram to kilogram scale for clinical trial material production.
• Reference Standard: Used as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	6-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidine]
CAS No.	180160-93-4
Molecular Formula	C12H14ClNO
Molecular Weight	223.70 g/mol
Synonyms	6-Chloro-3H-spiro[2-benzofuran-1,4'-piperidine]; 6-Chloro-3H-spiro[isobenzofuran-1,4'-piperidine]; 6-Chloro-3'H-spiro[isobenzofuran-1,4'-piperidine]; 6-Chloro-3H-spiro[1-benzofuran-1,4'-piperidine]; 180160-93-4; Spiro[isobenzofuran-1(3H),4'-piperidine], 6-chloro-; AKOS005258315; CS-0457425
EINECS	Contact for details

Quality Control

Our 6-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidine] is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to industry-standard analytical protocols, and specifications can be aligned with client requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.