Description

5-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidine] is a high-value, spirocyclic organic compound that serves as a critical building block in modern pharmaceutical and agrochemical research. Its unique fused-ring structure provides a versatile scaffold for the synthesis of novel molecules with targeted biological activity. This intermediate is primarily sought after by R&D chemists and process development scientists in the pharmaceutical industry for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic areas.
• Agrochemical Synthesis: Used in the design and synthesis of novel crop protection agents and pesticides, leveraging its heterocyclic framework.
• Chemical Biology Probe Development: Serves as a core structure for creating molecular probes to study biological pathways and protein functions.
• Material Science Research: Investigated as a monomer or building block for advanced polymers and functional materials with specific optical or electronic properties.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and scale-up projects for client-specific molecules.

Basic Information

Product Name	5-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidine]
CAS No.	180160-48-9
Molecular Formula	C12H12ClNO
Molecular Weight	221.68 g/mol
Synonyms	5-Chloro-1,4-dihydrospiro[isobenzofuran-1,4'-piperidine]; 5-Chloro-3H-spiro[2-benzofuran-1,4'-piperidine]; 5-Chlorospiro[isobenzofuran-1(3H),4'-piperidine]; Spiro[isobenzofuran-1(3H),4'-piperidine], 5-chloro-; 180160-48-9; 5-Chloro-3H-spiro[isobenzofuran-1,4'-piperidine]
EINECS	Contact for details

Quality Control

Our 5-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidine] is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or GMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.