Description

5-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One is a high-purity, heterocyclic organic compound featuring a unique spirocyclic architecture that combines isobenzofuran and piperidine motifs. This structural complexity makes it a critical advanced intermediate for the synthesis of novel pharmacologically active molecules. It is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Chemical Biology Probe Synthesis: Serves as a core scaffold for creating molecular probes to study biological pathways and protein functions.
• Fine Chemical Synthesis: Employed in multi-step synthetic routes to produce complex, high-value specialty chemicals.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	5-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One
CAS No.	180160-47-8
Molecular Formula	C12H12ClNO2
Molecular Weight	237.68 g/mol
Synonyms	5-Chloro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one; 5-Chloro-3H-spiro[isobenzofuran-1,4'-piperidine]-3-one; 5-Chloro-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one; 5-Chloro-3H-spiro[2-benzofuran-1,4'-piperidine]-3-one; 180160-47-8; Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one, 5-chloro-
EINECS	Contact for details

Quality Control

Our 5-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.