Description

6-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic molecular architecture. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of complex bioactive molecules. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the central nervous system (CNS) and oncology research domains.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and target validation.
• Academic & Contract Research: Supplied to universities and CROs (Contract Research Organizations) for exploratory synthetic chemistry and pharmacological research.
• Process Development & Scale-up: Utilized in the development and optimization of robust, scalable synthetic routes for potential commercial manufacturing.

Basic Information

Product Name	6-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One
CAS No.	180160-40-1
Molecular Formula	C12H12ClNO2
Molecular Weight	237.68 g/mol
Synonyms	6-Chloro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one; 6-Chloro-3H-spiro[isobenzofuran-1,4'-piperidine]-3-one; 6-Chloro-3-oxo-3H-spiro[isobenzofuran-1,4'-piperidine]; 180160-40-1; Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one, 6-chloro-
EINECS	Contact for details

Quality Control

Our 6-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.