Description

4-Methyl-2-(Trifluoromethanesulfonyl)Oxypyridine is a high-value trifluoromethanesulfonate (triflate) derivative of a substituted pyridine. This compound serves as a versatile and reactive synthetic intermediate, prized for its ability to act as an excellent leaving group in cross-coupling reactions and nucleophilic substitutions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly those requiring the introduction of fluorinated or heterocyclic motifs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the triflate group facilitates the introduction of specific bioactive moieties.
• Material Science Research: Employed in the creation of novel organic electronic materials and liquid crystals, leveraging its reactivity to form new carbon-carbon and carbon-heteroatom bonds.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed reactions such as Suzuki, Stille, and Negishi couplings for constructing biaryl and complex aromatic systems.
• Nucleophilic Substitution: The trifluoromethanesulfonyloxy group is an excellent leaving group, making this compound reactive towards a wide range of oxygen, nitrogen, and carbon nucleophiles.
• Fluorine Chemistry: Serves as a precursor for introducing fluorinated segments into target molecules, a critical strategy in modern drug design to improve metabolic stability and bioavailability.

Basic Information

Product Name	4-Methyl-2-(Trifluoromethanesulfonyl)Oxypyridine
CAS No.	179260-78-7
Molecular Formula	C7H6F3NO3S
Molecular Weight	241.19 g/mol
Synonyms	2-Pyridinol, 4-methyl-, 2-(trifluoromethanesulfonate); 4-Methyl-2-pyridinyl trifluoromethanesulfonate; 4-Methylpyridin-2-yl triflate; 2-Trifluoromethanesulfonyloxy-4-methylpyridine; 4-Methyl-2-(triflyloxy)pyridine; 4-Methyl-2-trifluoromethanesulfonatopyridine; 2-(Trifluoromethylsulfonyloxy)-4-methylpyridine
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-(Trifluoromethanesulfonyl)Oxypyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.