Description

tert-Butyl 2-(5-Bromopyridin-3-Yl)Pyrrolidine-1-Carboxylate CAS NO 179120-81-1 is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyridine core and a protected pyrrolidine moiety. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially those targeting protein-protein interactions and kinase inhibition.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space around the pyridine-pyrrolidine scaffold.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation pesticides and herbicides.
• Ligand Synthesis for Catalysis: Employed in the preparation of specialized ligands for transition metal-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 2-(5-Bromopyridin-3-Yl)Pyrrolidine-1-Carboxylate
CAS No.	179120-81-1
Molecular Formula	C14H19BrN2O2
Molecular Weight	327.22 g/mol
Synonyms	1-Boc-2-(5-bromo-3-pyridyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-2-(5-bromopyridin-3-yl)pyrrolidine; tert-Butyl 2-(5-bromo-3-pyridinyl)-1-pyrrolidinecarboxylate; 2-(5-Bromopyridin-3-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; 5-Bromo-3-(1-Boc-pyrrolidin-2-yl)pyridine; 179120-81-1; Boc-2-(5-Bromo-3-pyridyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(5-Bromopyridin-3-Yl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.