Description

(4-Bromo-3-Chlorophenoxy)(tert-Butyl)Dimethylsilane is a specialized organosilicon reagent featuring a halogenated phenoxy group protected by a tert-butyldimethylsilyl (TBDMS) moiety. This compound is a critical building block in advanced organic synthesis, particularly for the controlled introduction of substituted phenoxy groups under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing complex drug candidates, especially those requiring halogenated aromatic ether functionalities.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the bromo-chloro-phenoxy group is a core structural element.
• Material Science Research: Serves as a precursor for modifying surface properties or creating functionalized polymers and dendrimers.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig amination after selective deprotection or functional group transformation.
• Ligand and Catalyst Development: Utilized to construct sophisticated ligand frameworks for asymmetric catalysis.
• Protecting Group Chemistry: The TBDMS group can be used to protect the phenolic oxygen during multi-step synthetic sequences, with orthogonal deprotection strategies available.

Basic Information

Product Name	(4-Bromo-3-Chlorophenoxy)(tert-Butyl)Dimethylsilane
CAS No.	179120-53-7
Molecular Formula	C₁₂H₁₈BrClOSi
Molecular Weight	329.72 g/mol
Synonyms	tert-Butyl(4-bromo-3-chlorophenoxy)dimethylsilane; 4-Bromo-3-chlorophenoxy-tert-butyldimethylsilane; DTXSID60674491; (4-Bromo-3-chloro-phenoxy)-tert-butyl-dimethyl-silane; TBDMS ether of 4-bromo-3-chlorophenol; Silane, (4-bromo-3-chlorophenoxy)(1,1-dimethylethyl)dimethyl-; 1-((tert-Butyldimethylsilyl)oxy)-4-bromo-3-chlorobenzene
EINECS	Contact for details

Quality Control

Our (4-Bromo-3-Chlorophenoxy)(tert-Butyl)Dimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor purity grades to meet specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) in a desiccator to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.