Description

Carbamic Acid, [(1S,2S)-2-Hydroxy-1-Methyl-3-Butynyl]-, 1,1-Dimethylethyl Ester is a high-purity, chiral building block of significant interest in advanced organic synthesis. This compound is valued for its defined stereochemistry and functional groups, which enable the construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for complex target molecules.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (1S,2S) configuration into target compounds, crucial for biological activity.
• Protease Inhibitor Research: Serves as a precursor or intermediate in the synthesis of protease inhibitors, leveraging its hydroxy and carbamate functionalities.
• Peptidomimetics: Used in the design and synthesis of peptide analogs and mimetics for drug discovery programs.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Item	Details
Product Name	Carbamic Acid, [(1S,2S)-2-Hydroxy-1-Methyl-3-Butynyl]-, 1,1-Dimethylethyl Ester
CAS No.	178894-45-6
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	(1S,2S)-2-Hydroxy-1-methyl-3-butynylcarbamic acid tert-butyl ester; tert-Butyl N-[(1S,2S)-2-hydroxy-1-methyl-3-butynyl]carbamate; (1S,2S)-2-Hydroxy-1-methylbut-3-ynyl-carbamic acid tert-butyl ester; (2S,3S)-3-Hydroxy-1,2-dimethyl-3-butynyl carbamate tert-butyl; Boc-(1S,2S)-AHD; A Chiral Acetylenic Alcohol Derivative
EINECS	Contact for details

Quality Control

Every batch of Carbamic Acid, [(1S,2S)-2-Hydroxy-1-Methyl-3-Butynyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. We ensure compliance with high-purity standards suitable for research and pharmaceutical applications. Comprehensive analytical testing, including chiral purity verification by HPLC, is performed. A Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.