Description

Methyl (3R)-3-Amino-4-Phenylbutanoate Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its defined stereochemistry and functional groups make it a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for cardiovascular and neurological drugs. This compound is essential for research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and production of enantiomerically pure therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of renin inhibitors, antihypertensive agents, and other cardiovascular drugs.
• API Synthesis: Critical building block for the production of complex, enantiomerically pure Active Pharmaceutical Ingredients (APIs).
• Peptidomimetics Research: Used in medicinal chemistry for the design and development of peptide-like molecules with enhanced metabolic stability.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to construct complex molecular architectures.
• Biochemical Research: Utilized in academic and industrial R&D for studying enzyme inhibition and receptor-ligand interactions.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals requiring high stereochemical fidelity.

Basic Information

Product Name	Methyl (3R)-3-Amino-4-Phenylbutanoate Hydrochloride
CAS No.	178665-35-5
Molecular Formula	C11H16ClNO2
Molecular Weight	229.70 g/mol
Synonyms	(R)-Methyl 3-Amino-4-phenylbutanoate hydrochloride; Methyl (R)-3-Amino-4-phenylbutyrate HCl; (3R)-3-Amino-4-phenylbutanoic acid methyl ester hydrochloride; (R)-3-Amino-4-phenyl-butyric acid methyl ester hydrochloride; β-Amino-β-phenylbutyric acid methyl ester hydrochloride (R-form); Aliskiren intermediate; SPP676 intermediate; SPP-100 intermediate
EINECS	Contact for details

Quality Control

Our Methyl (3R)-3-Amino-4-Phenylbutanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.