Description

Imidazo[1,2-A]Pyridine, 8-Chloro-6-(Trifluoromethyl)- is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines an imidazopyridine scaffold with halogen and trifluoromethyl substituents, enabling precise modulation of electronic and steric properties in target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly as a key intermediate in medicinal chemistry programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, especially in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a specialized monomer or ligand in the development of advanced organic electronic materials, such as OLEDs or conductive polymers.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways in academic and industrial research.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Imidazo[1,2-A]Pyridine, 8-Chloro-6-(Trifluoromethyl)-
CAS No.	178488-36-3
Molecular Formula	C8H4ClF3N2
Molecular Weight	220.58 g/mol
Synonyms	8-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine; 6-(Trifluoromethyl)-8-chloroimidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine, 8-chloro-6-(trifluoromethyl)-; 8-Chloro-6-trifluoromethylimidazo[1,2-a]pyridine; 178488-36-3; 8-Cl-6-CF3-Imidazopyridine
EINECS	Contact for details

Quality Control

Every batch of Imidazo[1,2-A]Pyridine, 8-Chloro-6-(Trifluoromethyl)- is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for sensitive R&D and scale-up processes. A detailed Certificate of Analysis (COA) is supplied with each shipment, typically including results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP standards where applicable for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.