Description

Tafenoquine Succinate is a high-purity pharmaceutical salt form of the antimalarial compound tafenoquine. This product is critical for ensuring the efficacy and stability of finished drug formulations, particularly for the prophylaxis and radical cure of *Plasmodium vivax* malaria. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of anti-infective therapeutics.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key active component in the manufacture of finished dosage forms for malaria treatment and prevention.
• Antimalarial Drug Formulation: Specifically formulated for single-dose radical cure regimens targeting the dormant hypnozoites of *P. vivax* malaria.
• Research & Development: Serves as a critical reference standard and raw material in preclinical and clinical studies for new antimalarial therapies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of generic or branded pharmaceutical products.
• Combinatorial Therapy Development: Used in research exploring combination therapies to combat drug-resistant malaria strains.

Basic Information

Product Name	Tafenoquine Succinate
CAS No.	178429-62-4
Molecular Formula	C₂₄H₂₈F₃N₅O₃ • C₄H₆O₄
Molecular Weight	581.56 g/mol
Synonyms	Tafenoquine hydrogen succinate; Tafenoquine (succinate); WR 238605 succinate; (R,S)-Tafenoquine succinate; 4-[(2,6-Dimethoxy-4-methyl-5-[(3-trifluoromethyl)phenoxy]-8-quinolyl)amino]-2,6-dimethyl-1-piperidinecarboxylic acid, ethyl ester, succinate; Etaquine succinate; SB-252263 succinate
EINECS	Contact for details

Quality Control

Our Tafenoquine Succinate is manufactured under strict quality management systems. Each batch is tested to meet stringent specifications for identity, purity, and impurity profiles, aligning with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological quality is provided with every shipment to ensure full traceability and compliance for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.