Description

1H-Pyrrole-2-Acetonitrile, 1-Acetyl-2,5-Dihydro-, (R)- (9Ci) is a high-value, chiral pyrrole derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its enantiopure (R)-configuration and functionalized pyrrole-acetonitrile structure make it indispensable for constructing complex, biologically active molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where its pyrrole core can contribute to unique modes of action.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce chirality into more complex molecular architectures.
• Fine Chemical Production: Serves as a precursor for the manufacture of specialty chemicals, dyes, and functional materials requiring a substituted pyrrole framework.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and the exploration of new chemical spaces.

Basic Information

Product Name	1H-Pyrrole-2-Acetonitrile, 1-Acetyl-2,5-Dihydro-, (R)- (9Ci)
CAS No.	178206-94-5
Molecular Formula	C8H10N2O
Molecular Weight	150.18 g/mol
Synonyms	(R)-1-Acetyl-2,5-dihydro-1H-pyrrole-2-acetonitrile; 1-Acetyl-2,5-dihydro-(R)-1H-pyrrole-2-acetonitrile; (R)-1-Acetyl-2,5-dihydropyrrole-2-acetonitrile; 2,5-Dihydro-1H-pyrrole-2-acetonitrile, 1-acetyl-, (R)-; (R)-1-(2-Cyanoethyl)-2,5-dihydro-1H-pyrrole-1-acetate (tautomeric form); Chiral pyrrole nitrile intermediate; (R)-enantiomer of 1-Acetyl-2,5-dihydro-1H-pyrrole-2-acetonitrile
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrole-2-Acetonitrile, 1-Acetyl-2,5-Dihydro-, (R)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques, including chiral HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.