Description

Carbamic Acid, (3-Fluoropropyl)-, 1,1-Dimethylethyl Ester (9Ci) CAS NO 178181-51-6 is a specialized tert-butyl carbamate derivative featuring a fluoropropyl side chain, serving as a crucial protected amine intermediate in advanced organic synthesis. This compound matters for its role in introducing fluorinated motifs into target molecules, a strategy widely used to modulate the physicochemical and pharmacokinetic properties of pharmaceuticals and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel fluorinated pesticides and herbicides, where the fluorine atom can enhance biological activity and environmental stability.
• Peptide Chemistry & PROTACs: Serves as a protected amine synthon in the solid-phase and solution-phase synthesis of fluorinated peptides and proteolysis-targeting chimeras (PROTACs).
• Material Science Precursor: Employed in the development of fluorinated polymers, coatings, and liquid crystals with tailored surface properties and stability.
• Chemical Biology Probes: Utilized to create fluorinated probes and linkers for studying biological mechanisms and enzyme activity.
• Scale-up & Process Chemistry: A reliable intermediate for kilogram-scale GMP and non-GMP production, offering consistent quality for process optimization.

Basic Information

Product Name	Carbamic Acid, (3-Fluoropropyl)-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	178181-51-6
Molecular Formula	C8H16FNO2
Molecular Weight	177.22 g/mol
Synonyms	tert-Butyl (3-fluoropropyl)carbamate; N-(3-Fluoropropyl)carbamic Acid tert-Butyl Ester; 1,1-Dimethylethyl N-(3-Fluoropropyl)carbamate; 3-Fluoropropylcarbamic Acid tert-Butyl Ester; Boc-3-fluoropropylamine; N-Boc-3-fluoropropylamine; (3-Fluoropropyl)carbamic Acid tert-Butyl Ester; tert-Butyl 3-fluoropropylcarbamate
EINECS	Contact for details

Quality Control

Our Carbamic Acid, (3-Fluoropropyl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can support standards relevant to research and development, and we are committed to meeting the specific quality requirements of your project.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.