Description

Cyclopropanecarboxylic Acid, 2-Acetyl-, (1R-Cis)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its unique fused cyclopropane-acetyl moiety makes it a valuable precursor for constructing complex molecular architectures with precise three-dimensional control. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, where its defined stereochemistry is critical for biological activity and process reproducibility. CAS No. 178033-28-8.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex, constrained molecular frameworks.
• Agrochemical Synthesis: Used in the design and production of advanced crop protection agents and pesticides, where the cyclopropane ring can confer specific biological activity and stability.
• Asymmetric Catalysis & Ligand Development: Serves as a precursor for chiral ligands or catalysts used in enantioselective synthesis to produce single-isomer compounds.
• Material Science Research: Investigated as a monomer or building block for novel polymers and advanced materials with unique physical properties.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tool compounds for studying biological systems and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical manufacturers for use in custom synthesis projects and scale-up campaigns for client-specific molecules.

Basic Information

Item	Details
Product Name	Cyclopropanecarboxylic Acid, 2-Acetyl-, (1R-Cis)- (9Ci)
CAS No.	178033-28-8
Molecular Formula	C6H8O3
Molecular Weight	128.13 g/mol
Synonyms	(1R,2S)-2-Acetylcyclopropanecarboxylic Acid; (1R-cis)-2-Acetylcyclopropanecarboxylic Acid; (1R,2S)-2-Acetyl-1-cyclopropanecarboxylic Acid; cis-2-Acetylcyclopropanecarboxylic Acid (1R,2S)-; 2-Acetylcyclopropanecarboxylic Acid, (1R-cis)-; (1R,2S)-rel-2-Acetylcyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Acetyl-, (1R-Cis)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.