Description

2'-Azido-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)Uridine is a key nucleoside derivative and a critical building block in oligonucleotide synthesis, particularly for the preparation of azide-functionalized nucleic acids. This compound is essential for researchers and manufacturers developing advanced therapeutic oligonucleotides, such as antisense drugs and siRNA, where it enables site-specific conjugation and labeling. It is primarily used in pharmaceutical R&D, biotechnology, and academic research focused on nucleic acid chemistry and drug discovery.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for the solid-phase synthesis of azide-modified DNA and RNA strands.
• Click Chemistry: The azido group facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) for precise bioconjugation with dyes, peptides, or other functional molecules.
• Antisense & siRNA Therapeutics: Used in the research and development of novel therapeutic oligonucleotides requiring targeted delivery or tracking.
• Diagnostic Probe Development: Enables the creation of labeled nucleic acid probes for imaging and diagnostic assays.
• Chemical Biology Research: A tool for studying nucleic acid structure, function, and interactions through bioorthogonal labeling strategies.
• Material Science: Used in the fabrication of functionalized surfaces and nanomaterials via nucleic acid templating.

Basic Information

Product Name	2'-Azido-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)Uridine
CAS No.	177980-10-8
Molecular Formula	C30H29N5O7
Molecular Weight	571.59 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-azido-2'-deoxyuridine; 2'-Azido-2'-deoxy-5'-O-DMT-uridine; 2'-N3-2'-dU(DMT); DMT-2'-Azido-2'-deoxyuridine; 2'-Azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine; 2'-Azido-2'-deoxyuridine DMT ether; Azido-DMT-dU; 2'-N3-dU(DMT)
EINECS	Contact for details

Quality Control

Our 2'-Azido-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)Uridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and oligonucleotide synthesis. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; desiccants are recommended for long-term storage. Keep container tightly sealed under an inert atmosphere when not in use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.