Description

Methyl (3S)-3-Amino-3-(4-Hydroxyphenyl)Propanoate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the production of advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Neurological Drug Research: Used in the development of compounds targeting central nervous system disorders.
• Metabolic Disease Therapeutics: Serves as a precursor in the synthesis of drugs for diabetes and related metabolic conditions.
• Asymmetric Synthesis: Employed in chiral synthesis due to its defined (3S) stereochemistry for creating enantiomerically pure compounds.
• Peptidomimetics Development: Acts as a constrained amino acid derivative in the design of peptide-based drugs.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and process development projects.

Basic Information

Item	Detail
Product Name	Methyl (3S)-3-Amino-3-(4-Hydroxyphenyl)Propanoate
CAS No.	177966-65-3
Molecular Formula	C10H13NO3
Molecular Weight	195.22 g/mol
Synonyms	(3S)-3-Amino-3-(4-hydroxyphenyl)propanoic acid methyl ester; Methyl L-3-Amino-3-(4-hydroxyphenyl)propionate; (S)-Methyl 3-amino-3-(4-hydroxyphenyl)propanoate; Methyl (S)-3-Amino-3-(4-hydroxyphenyl)propanoate; 4-Hydroxy-L-phenylalanine methyl ester derivative; 3-Amino-3-(4-hydroxyphenyl)propionic acid methyl ester (S-form); L-3-(4-Hydroxyphenyl)alanine methyl ester
EINECS	Contact for details

Quality Control

Our Methyl (3S)-3-Amino-3-(4-Hydroxyphenyl)Propanoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). The product undergoes rigorous testing, including chiral purity analysis by HPLC, to meet the exacting standards of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.