Description

6-Fluoro-2,3,4,5-Tetrahydro-1H-Pyrido-[4,3-B]Indole Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex fused-ring structure. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those with indole and tetrahydro-β-carboline scaffolds.
• Neurological Research: Serves as a core structure for developing compounds targeting serotonin and dopamine receptors for potential CNS applications.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization programs in drug discovery.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in API manufacturing.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and novel synthetic pathways.

Basic Information

Item	Details
Product Name	6-Fluoro-2,3,4,5-Tetrahydro-1H-Pyrido-[4,3-B]Indole Hydrochloride
CAS No.	177858-77-4
Molecular Formula	C12H14ClFN2
Molecular Weight	240.70 g/mol
Synonyms	6-Fluoro-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole hydrochloride; 6-Fluoro-2,3,4,9-tetrahydro-1H-β-carboline hydrochloride; 6-Fluoro-9H-pyrido[3,4-b]indole, 1,2,3,4-tetrahydro-, hydrochloride; 6-Fluoro-tetrahydro-β-carboline HCl; 6-F-THBC hydrochloride; 177858-77-4 (CAS); 6-Fluoro-1,2,3,4-tetrahydro-β-carboline hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Fluoro-2,3,4,5-Tetrahydro-1H-Pyrido-[4,3-B]Indole Hydrochloride is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.