Description

(E)-2,2-Dimethyl-Propanoic Acid 4-[4-Chloro-1-(4-Hydroxyphenyl)-2-Phenyl-1-Butenyl]Phenyl Ester is a high-purity, non-steroidal selective estrogen receptor modulator (SERM) intermediate of significant commercial and research interest. This compound is critical for the synthesis of advanced pharmaceutical agents targeting hormone-responsive conditions. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutics.

Application

• Key Intermediate in SERM Synthesis: Serves as a crucial building block for the production of selective estrogen receptor modulators and related therapeutic compounds.
• Pharmaceutical Research & Development: Used in preclinical and discovery-phase studies for investigating new treatments for breast cancer, osteoporosis, and other hormone-related disorders.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Process Chemistry: Utilized in route scouting and optimization for the scalable manufacturing of complex active pharmaceutical ingredients (APIs).
• Biochemical Research: Applied in studies of estrogen receptor binding affinity, mechanism of action, and structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	(E)-2,2-Dimethyl-Propanoic Acid 4-[4-Chloro-1-(4-Hydroxyphenyl)-2-Phenyl-1-Butenyl]Phenyl Ester
CAS No.	177748-18-4
Molecular Formula	C29H29ClO3
Molecular Weight	461.00 g/mol
Synonyms	4-[4-Chloro-1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenyl pivalate; (E)-4-[4-Chloro-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl]phenyl 2,2-dimethylpropanoate; Bazedoxifene Intermediate; Bazedoxifene Related Compound; TSE-424 Intermediate; WAY-140424 Intermediate; (E)-Pivalic Acid 4-[4-Chloro-1-(4-Hydroxyphenyl)-2-Phenyl-1-Butenyl]Phenyl Ester
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.