Description

2-(Benzyloxy)-3-Chloropyridine is a high-purity, versatile heterocyclic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a benzyl-protected oxygen and a reactive chlorine substituent on the pyridine ring, makes it a critical intermediate for constructing complex pharmacophores. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries. It enables the efficient synthesis of novel active ingredients and fine chemicals requiring specific substitution patterns.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the chloropyridine moiety is a common structural motif.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or light-emitting components.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic and Industrial R&D: Essential for medicinal chemistry programs and process chemistry optimization in both academic and industrial laboratory settings.

Basic Information

Product Name	2-(Benzyloxy)-3-Chloropyridine
CAS No.	177743-07-6
Molecular Formula	C₁₂H₁₀ClNO
Molecular Weight	219.67 g/mol
Synonyms	3-Chloro-2-(phenylmethoxy)pyridine; 2-Benzyloxy-3-chloropyridine; 3-Chloro-2-(benzyloxy)pyridine; 2-(Benzyloxy)-3-chloropyridine; 3-Chloro-2-pyridinyl phenylmethyl ether; Pyridine, 3-chloro-2-(phenylmethoxy)-; 177743-07-6; Benzyl 3-chloro-2-pyridyl ether
EINECS	Contact for details

Quality Control

Our 2-(Benzyloxy)-3-Chloropyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, GC for residual solvents, and spectroscopic methods for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity (HPLC)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.