Description

3',5'-Difluoro-Biphenyl-3-Carboxylic Acid is a high-purity fluorinated biphenyl derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its unique molecular structure, which combines a carboxylic acid functional group with strategically placed fluorine atoms, enabling precise modifications to enhance the properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning molecular interactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and pesticides, where the fluorine atoms improve bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core structure for creating fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Polymer Modification: Employed to introduce fluorinated biphenyl units into polymer backbones, enhancing thermal stability, chemical resistance, and optical clarity of high-performance plastics.
• Chemical Research & Development: A versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Advanced Material Science: Used in the development of specialty coatings and electronic materials that require specific dielectric properties and resistance to degradation.

Basic Information

Product Name	3',5'-Difluoro-Biphenyl-3-Carboxylic Acid
CAS No.	177734-83-7
Molecular Formula	C13H8F2O2
Molecular Weight	234.20 g/mol
Synonyms	[3-(3,5-Difluorophenyl)phenyl]carboxylic acid; 3',5'-Difluoro[1,1'-biphenyl]-3-carboxylic acid; 3-(3,5-Difluorophenyl)benzoic acid; Biphenyl-3-carboxylic acid, 3',5'-difluoro-; 3-Carboxy-3',5'-difluorobiphenyl; 3-(3,5-Difluorophenyl)benzoic Acid
EINECS	Contact for details

Quality Control

Our 3',5'-Difluoro-Biphenyl-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed when not in use to prevent any potential moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.