Description

3-Hydroxymethyl-5-Iodo-Benzoic Acid Methyl Ester is a versatile iodinated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its bifunctional structure, featuring both a hydroxymethyl group and an ester moiety, which allows for selective chemical modifications. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of complex molecules, particularly in medicinal chemistry programs targeting novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring an iodinated aromatic core for further cross-coupling reactions.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization stages for creating diverse compound libraries via modifications at the hydroxymethyl and ester functional groups.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, or plant growth regulators that incorporate halogenated benzoate structures.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis or as a scaffold for functional materials.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags, leveraging the iodine atom for radiolabeling (e.g., with I-125) or bioconjugation strategies.
• Advanced Material Precursor: Potential monomer or intermediate in the synthesis of specialty polymers and liquid crystals.

Basic Information

Product Name	3-Hydroxymethyl-5-Iodo-Benzoic Acid Methyl Ester
CAS No.	177734-81-5
Molecular Formula	C9H9IO3
Molecular Weight	292.07 g/mol
Synonyms	Methyl 3-(Hydroxymethyl)-5-iodobenzoate; 5-Iodo-3-(hydroxymethyl)benzoic Acid Methyl Ester; Benzoic acid, 3-(hydroxymethyl)-5-iodo-, methyl ester; Methyl 5-iodo-3-(hydroxymethyl)benzoate; 3-(Hydroxymethyl)-5-iodobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-Hydroxymethyl-5-Iodo-Benzoic Acid Methyl Ester is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.