Description

Carbamic Acid, [2-(Hydroxymethyl)Cyclopropyl]-, 1,1-Dimethylethyl Ester, (1S- CAS NO 177472-60-5 is a specialized chiral building block featuring a cyclopropane ring with a hydroxymethyl substituent, protected as a tert-butyl carbamate (Boc). This compound is valued for its role in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily sought after by medicinal chemists and process development scientists working on novel therapeutic agents, including protease inhibitors and other small-molecule drugs where the rigid cyclopropane scaffold is crucial for activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially those targeting viral proteases or neurological disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce conformational constraint and modulate pharmacokinetic properties.
• Peptidomimetic Development: Serves as a proline or other amino acid analog in the design of peptide-like molecules with enhanced metabolic stability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective reactions to construct complex molecular architectures.
• Process Chemistry: Used in the scale-up and route development for the commercial manufacturing of advanced drug candidates.
• Bioconjugation & Probe Synthesis: The protected amine (Boc group) and hydroxymethyl functionality allow for further derivatization to create chemical probes for biological studies.

Basic Information

Product Name	Carbamic Acid, [2-(Hydroxymethyl)Cyclopropyl]-, 1,1-Dimethylethyl Ester, (1S-
CAS No.	177472-60-5
Molecular Formula	C10H17NO3
Molecular Weight	199.25 g/mol
Synonyms	(1S)-2-(Hydroxymethyl)cyclopropanecarboxylic acid tert-butylamide; (1S)-N-(tert-Butoxycarbonyl)-2-(hydroxymethyl)cyclopropanamine; (1S)-2-(Hydroxymethyl)cyclopropylcarbamic acid tert-butyl ester; tert-Butyl (1S)-2-(hydroxymethyl)cyclopropylcarbamate; (1S)-Boc-2-(hydroxymethyl)cyclopropylamine; (S)-tert-Butyl (2-(hydroxymethyl)cyclopropyl)carbamate; (1S)-2-(Hydroxymethyl)-1-cyclopropanamine, N-Boc-; Boc-Cyclopropane-(S)-aminomethanol
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as assay (HPLC), chiral purity, and residual solvent levels. We support compliance with ICH guidelines and can provide material suitable for use under cGMP conditions for non-clinical and clinical-stage applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.