Description

2-(T-Butyldimethylsilyloxy)-4-Bromoanisole is a high-value, protected phenolic intermediate essential for advanced organic synthesis. This compound matters because its orthogonal protecting group and halogen functionality enable precise, multi-step chemical transformations in controlled environments. Pharmaceutical, agrochemical, and advanced materials researchers need it for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty chemicals where selective deprotection and further functionalization are required.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in catalytic systems and material science.
• Advanced Material Development: Employed in the creation of organic electronic materials, liquid crystals, and polymers with specific functionalities.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D in synthetic organic chemistry, enabling novel reaction pathways.
• Custom Synthesis Projects: Provides a critical, protected starting point for contract research organizations (CROs) and custom synthesis manufacturers.

Basic Information

Product Name	2-(T-Butyldimethylsilyloxy)-4-Bromoanisole
CAS No.	177329-71-4
Molecular Formula	C13H21BrO2Si
Molecular Weight	317.30 g/mol
Synonyms	4-Bromo-2-[(tert-butyldimethylsilyl)oxy]anisole; 2-Bromo-5-methoxyphenol tert-butyldimethylsilyl ether; 1-Bromo-4-methoxy-2-[(tert-butyldimethylsilyl)oxy]benzene; 4-Bromo-2-(TBDMSO)anisole; 2-(tert-Butyldimethylsiloxy)-4-bromoanisole; Anisole, 4-bromo-2-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; TBDMS Protected 4-Bromoguaiacol
EINECS	Contact for details

Quality Control

Our 2-(T-Butyldimethylsilyloxy)-4-Bromoanisole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production use. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.