Description

Ethyl 2-Ethoxymethylene-4,4-Difluoro(Acetoacetate) is a high-value fluorinated building block and a key intermediate in organic synthesis. Its molecular structure, featuring a difluoromethylene group and a reactive ethoxymethylene acetoacetate moiety, makes it indispensable for constructing complex molecules with enhanced properties. This compound is primarily sought after by pharmaceutical, agrochemical, and advanced material research sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in the development of antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to create novel fluorinated pesticides, herbicides, and fungicides, where the fluorine atoms can improve metabolic stability, bioavailability, and membrane permeability.
• Advanced Material Research: Serves as a monomer or building block for developing specialty polymers, liquid crystals, and organic electronic materials with unique optical or electrical properties.
• Fluorine Chemistry & R&D: An essential reagent in academic and industrial research laboratories for exploring new fluorination methodologies and creating novel fluoroorganic compounds.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring the introduction of a difluoroacetoacetate unit into complex molecular architectures.

Basic Information

Product Name	Ethyl 2-Ethoxymethylene-4,4-Difluoro(Acetoacetate)
CAS No.	176969-33-8
Molecular Formula	C9H12F2O4
Molecular Weight	222.19 g/mol
Synonyms	Ethyl 2-(Ethoxymethylene)-4,4-difluoro-3-oxobutanoate; 4,4-Difluoro-2-(ethoxymethylene)-3-oxobutanoic Acid Ethyl Ester; Ethyl 4,4-Difluoro-2-(ethoxymethylene)acetoacetate; Ethyl (Ethoxymethylene)difluoroacetoacetate; EDFA; Difluoro Ethoxymethylene Acetoacetate Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Ethoxymethylene-4,4-Difluoro(Acetoacetate) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for pharmaceutical intermediate use. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support our clients with full traceability and documentation to meet the stringent requirements of cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.