Description

1-tert-Butyl 3-Ethyl 4-(Trifluoromethylsulfonyloxy)-5,6-Dihydropyridine-1,3(2H)-Dicarboxylate is a high-value, protected dihydropyridine derivative featuring a reactive trifluoromethanesulfonate (triflate) leaving group. This compound serves as a critical synthetic intermediate for constructing complex nitrogen-containing heterocycles, enabling advanced medicinal chemistry and materials science research. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for the development of novel active pharmaceutical ingredients (APIs) and specialized organic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel dihydropyridine and piperidine-based drug candidates, particularly in cardiovascular and neurological therapeutic areas.
• Cross-Coupling Reactions: The triflate group enables efficient palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for introducing complex substituents at the 4-position of the dihydropyridine ring.
• Medicinal Chemistry Scaffold Development: Used to create diverse chemical libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Fine Chemical Synthesis: Intermediate in the multi-step synthesis of complex natural product analogs and specialty agrochemicals.
• Material Science Precursor: Potential starting material for the synthesis of nitrogen-doped organic semiconductors or ligands for catalytic systems.

Basic Information

Product Name	1-tert-Butyl 3-Ethyl 4-(Trifluoromethylsulfonyloxy)-5,6-Dihydropyridine-1,3(2H)-Dicarboxylate
CAS No.	176525-98-7
Molecular Formula	C15H22F3NO7S
Molecular Weight	417.40 g/mol
Synonyms	1-tert-Butyl 3-ethyl 4-(trifluoromethanesulfonyloxy)-1,2,3,6-tetrahydropyridine-1,3-dicarboxylate; 4-(Trifluoromethylsulfonyloxy)-1,2,3,6-tetrahydropyridine-1,3-dicarboxylic Acid 1-tert-Butyl 3-Ethyl Ester; 1-Boc-3-Ethyl 4-Triflyloxy-1,2,3,6-tetrahydropyridine-1,3-dicarboxylate; tert-Butyl Ethyl 4-(Trifluoromethanesulfonyloxy)-1,2,3,6-tetrahydropyridine-1,3-dicarboxylate; 4-OTf Dihydropyridine Ester; CAS 176525-98-7
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 3-Ethyl 4-(Trifluoromethylsulfonyloxy)-5,6-Dihydropyridine-1,3(2H)-Dicarboxylate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, critical for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.