Description

L-Proline, 1-(Aminoiminomethyl)-4-Hydroxy-, (4R)- (9Ci) is a high-purity, non-proteinogenic amino acid derivative with a complex, functionalized structure. This compound is a critical chiral building block and intermediate in advanced pharmaceutical synthesis and biochemical research. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing novel therapeutics, peptide-based drugs, and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates, particularly protease inhibitors and other bioactive molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce specialized proline derivatives with modified side chains.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly those involving amino acid metabolism or proline-specific enzymes.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions due to its defined stereochemistry.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	L-Proline, 1-(Aminoiminomethyl)-4-Hydroxy-, (4R)- (9Ci)
CAS No.	176370-06-2
Molecular Formula	C7H13N3O3
Molecular Weight	187.20 g/mol
Synonyms	(4R)-1-(Aminoiminomethyl)-4-hydroxy-L-proline; 4-Hydroxy-1-amidinoproline; 1-Amidino-4-hydroxy-L-proline; 1-Carbamimidoyl-4-hydroxy-L-proline; 4-Hydroxy-1-guanyl-L-proline; (2S,4R)-1-Carbamimidoyl-4-hydroxypyrrolidine-2-carboxylic acid; L-1-Amidino-4-hydroxyproline; A high-purity derivative of 4-hydroxy-L-proline.
EINECS	Contact for details

Quality Control

Our L-Proline, 1-(Aminoiminomethyl)-4-Hydroxy-, (4R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identification by IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.