Description

L-Aspartic Acid 1-tert-Butyl Ester Hydrochloride is a protected amino acid derivative essential for advanced organic synthesis. This compound is a critical building block for the preparation of peptides and peptidomimetics, offering a reactive carboxyl group while the tert-butyl ester group provides orthogonal protection. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, bioactive peptides, and complex organic molecules where precise stereochemistry and functional group manipulation are required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of aspartic acid.
• Biochemical Research: Serves as a precursor in the study of enzyme inhibitors, receptor ligands, and metabolic pathway modulators.
• Prodrug Development: Employed in the design of prodrugs where the tert-butyl ester can be cleaved under specific physiological conditions.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in catalytic asymmetric reactions to construct complex molecular architectures.
• Protecting Group Strategy: Integral to multi-step synthetic routes requiring orthogonal protection of carboxylic acid functionalities.

Basic Information

Product Name	L-Aspartic Acid 1-tert-Butyl Ester Hydrochloride
CAS No.	176164-02-6
Molecular Formula	C8H16ClNO4
Molecular Weight	225.67 g/mol
Synonyms	H-Asp(OtBu)-OH·HCl; L-Aspartic acid β-tert-butyl ester hydrochloride; (S)-2-Amino-3-(tert-butoxycarbonyl)propanoic acid hydrochloride; (S)-3-(tert-Butoxy)-2-aminosuccinic acid 1-hydrochloride; Aspartic acid 1-tert-butyl ester hydrochloride, L-; tert-Butyl L-aspartate hydrochloride; Boc-L-Aspartic acid α-benzyl ester hydrochloride (common mis-association); Fmoc-Asp(OtBu)-OH precursor
EINECS	Contact for details

Quality Control

Our L-Aspartic Acid 1-tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided to guarantee consistent quality, identity, and purity for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity ([α]D)	≥99.0% ee
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Solubility	Clear, colorless solution in specified solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.