Description

(S)-2-Amino-tert-Butyldimethylsilyloxypropane is a high-purity, chiral silyl-protected amino alcohol building block of significant importance in advanced organic synthesis. Its primary value lies in serving as a key intermediate for the preparation of complex pharmaceutical compounds, particularly in the synthesis of chiral ligands and active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), especially in antiviral and cardiovascular drug candidates.
• Chiral Ligand Synthesis: Used as a precursor for the development of novel chiral ligands and catalysts employed in asymmetric hydrogenation and other stereoselective transformations.
• Peptidomimetics & Amino Acid Derivatives: Facilitates the synthesis of modified peptides and non-natural amino acid derivatives with enhanced metabolic stability for drug discovery.
• Agrochemical Synthesis: Employed in the research and development of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry is required for bioactivity.
• Material Science Research: Acts as a functional monomer or cross-linker in the development of specialized polymers and advanced materials with tailored properties.

Basic Information

Product Name	(S)-2-Amino-tert-Butyldimethylsilyloxypropane
CAS No.	175717-75-6
Molecular Formula	C9H23NOSi
Molecular Weight	189.37 g/mol
Synonyms	(S)-1-Amino-2-((tert-butyldimethylsilyl)oxy)propane; (S)-2-((tert-Butyldimethylsilyl)oxy)propylamine; (S)-1-Amino-2-(TBDMSO)propane; (S)-2-(tert-Butyldimethylsilyloxy)-1-propylamine; (S)-2-Amino-1-(tert-butyldimethylsilyloxy)propane; (S)-TBDMS-Aminopropanol; (S)-O-TBDMS-2-Aminopropanol; (S)-2-(N-TBDMS)aminopropanol
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-tert-Butyldimethylsilyloxypropane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is subjected to rigorous analytical testing, including chiral HPLC, NMR, and GC, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.