Description

1,4- Dihydro-2,6-Dimethyl-3-(2-Cyanoethoxycarbonyl)-5-Ethoxycarbonyl-4-(2,3-Dichlorophenyl)Pyridine is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its precise structure is essential for biological activity. It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development and production of next-generation therapeutics.

Application

• Key Intermediate in API Synthesis: Primarily used in the multi-step synthesis of complex pharmaceutical compounds, particularly calcium channel blockers and other cardiovascular agents.
• Research & Development (R&D): Serves as a crucial reagent in medicinal chemistry for the discovery and optimization of new drug candidates.
• Process Chemistry: Employed in scale-up and process optimization studies within fine chemical and pharmaceutical manufacturing.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Custom Synthesis: A starting material for the custom synthesis of specialized derivatives and analogs for biological testing.

Basic Information

Product Name	1,4- Dihydro-2,6-Dimethyl-3-(2-Cyanoethoxycarbonyl)-5-Ethoxycarbonyl-4-(2,3-Dichlorophenyl)Pyridine
CAS No.	175688-78-5
Molecular Formula	C22H22Cl2N2O4
Molecular Weight	449.33 g/mol
Synonyms	4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-(2-cyanoethyl) 5-ethyl ester; Felodipine Intermediate; Felodipine Related Compound; 2-Cyanoethyl 5-ethoxycarbonyl-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3-pyridinecarboxylate; Ethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 3-(2-cyanoethyl) ester; CAS 175688-78-5
EINECS	Contact for details

Quality Control

Our 1,4- Dihydro-2,6-Dimethyl-3-(2-Cyanoethoxycarbonyl)-5-Ethoxycarbonyl-4-(2,3-Dichlorophenyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.