Description

Propanedioic Acid, (Phenylmethyl)-, Monoethyl Ester, (R)- (9Ci) is a chiral, non-racemic organic compound belonging to the class of substituted malonic acid monoesters. This high-purity intermediate is critical for the synthesis of enantiomerically pure pharmaceuticals and advanced organic molecules, where stereochemical integrity directly impacts biological activity and process efficiency. It is primarily sought by research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Asymmetric Synthesis: Used in stereoselective carbon-carbon bond-forming reactions, such as Michael additions and alkylations, to introduce the (R)-configured benzylmalonate moiety.
• Agrochemical Research: Serves as a precursor in the development of chiral herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Utilized for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical Production: An essential intermediate for manufacturing specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for custom synthesis projects in contract research organizations (CROs).

Basic Information

Product Name	Propanedioic Acid, (Phenylmethyl)-, Monoethyl Ester, (R)- (9Ci)
CAS No.	175521-78-5
Molecular Formula	C₁₂H₁₄O₄
Molecular Weight	222.24 g/mol
Synonyms	(R)-Benzylmalonic Acid Monoethyl Ester; (R)-Monoethyl Benzylmalonate; (R)-1-Ethoxy-1-oxo-3-phenylpropan-2-yl Hydrogen Propanedioate; Ethyl (R)-2-Benzyl-3-hydroxy-3-oxopropanoate; (R)-α-Benzylmalonic Acid Monoethyl Ester; Monoethyl (R)-Benzylmalonate; (R)-Benzylmalonic Acid Ethyl Ester (partial ester)
EINECS	Contact for details

Quality Control

Our Propanedioic Acid, (Phenylmethyl)-, Monoethyl Ester, (R)- (9Ci) is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is stable under inert atmosphere. Keep away from strong bases and incompatible materials such as oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.