Description

5-Bromo-1-Methyl-1H-Pyrrolo[2,3-B]Pyridin-2(3H)-One is a high-purity, advanced pharmaceutical intermediate and heterocyclic building block of significant commercial interest. Its value lies in its role as a key synthetic precursor for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and kinase inhibitor research. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of targeted small-molecule drugs.
• Kinase Inhibitor Development: Serves as a core scaffold for creating potent and selective kinase inhibitors for cancer therapy.
• Agrochemical Research: Used in the discovery and synthesis of new generation herbicides and fungicides with novel modes of action.
• Material Science: A precursor for organic electronic materials and functional dyes due to its fused heterocyclic structure.
• Contract Research & Manufacturing: Supplied to CROs and CDMOs for custom synthesis and process development projects.
• Academic & Discovery Chemistry: Utilized in medicinal chemistry programs for library synthesis and structure-activity relationship (SAR) studies.

Basic Information

Product Name	5-Bromo-1-Methyl-1H-Pyrrolo[2,3-B]Pyridin-2(3H)-One
CAS No.	175424-31-4
Molecular Formula	C8H7BrN2O
Molecular Weight	227.06 g/mol
Synonyms	5-Bromo-1-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-one; 5-Bromo-1-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 5-Bromo-1-methyl-3H-pyrrolo[2,3-b]pyridin-2-one; 1-Methyl-5-bromo-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 2H-Pyrrolo[2,3-b]pyridin-2-one, 5-bromo-1,3-dihydro-1-methyl-; 175424-31-4; 5-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-Methyl-1H-Pyrrolo[2,3-B]Pyridin-2(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.