Description

2-(Aminomethyl)-3-Chloro-5-(Trifluoromethyl)-Pyridine Hydrochloride is a high-purity, halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an aminomethyl group and a trifluoromethyl substituent, makes it a versatile intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, such as herbicides and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Chemical Research & Development: Serves as a versatile building block in academic and industrial R&D for constructing complex heterocyclic compounds and exploring new chemical spaces.
• Ligand and Catalyst Preparation: The aminomethyl functionality allows for its use in the synthesis of specialized ligands and organocatalysts for asymmetric synthesis.
• Material Science Precursor: Potential use in the synthesis of functionalized polymers or organic electronic materials due to its aromatic core and reactive sites.

Basic Information

Product Name	2-(Aminomethyl)-3-Chloro-5-(Trifluoromethyl)-Pyridine Hydrochloride
CAS No.	175277-74-4
Molecular Formula	C8H7ClF3N2•HCl
Molecular Weight	261.51 g/mol (Free base: 224.60 g/mol)
Synonyms	3-Chloro-5-(trifluoromethyl)-2-pyridinemethanamine hydrochloride; 2-(Aminomethyl)-3-chloro-5-(trifluoromethyl)pyridine HCl; 3-Chloro-5-trifluoromethyl-2-pyridylmethylamine hydrochloride; (3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methanamine hydrochloride; 2-Pyridinemethanamine, 3-chloro-5-(trifluoromethyl)-, hydrochloride; 175277-74-4; 3-Chloro-5-trifluoromethyl-pyridine-2-ylmethylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Aminomethyl)-3-Chloro-5-(Trifluoromethyl)-Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.