Description

2-Methoxy-4-(Trifluoromethyl)Pyridine-3-Carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core substituted with methoxy and trifluoromethyl groups. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific pharmacokinetic profiles. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new drug candidates and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug molecules, especially in oncology and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging the biological activity of the trifluoromethylpyridine moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials and functional dyes due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke chemical production and scale-up projects.

Basic Information

Item	Detail
Product Name	2-Methoxy-4-(Trifluoromethyl)Pyridine-3-Carboxamide
CAS No.	175277-68-6
Molecular Formula	C8H7F3N2O2
Molecular Weight	220.15 g/mol
Synonyms	3-Carbamoyl-2-methoxy-4-(trifluoromethyl)pyridine; 2-Methoxy-4-trifluoromethylnicotinamide; 4-(Trifluoromethyl)-2-methoxypyridine-3-carboxamide; 175277-68-6; Nicotinamide, 2-methoxy-4-(trifluoromethyl)-; 2-Methoxy-4-(trifluoromethyl)-3-pyridinecarboxamide
EINECS	Contact for details

Quality Control

Our 2-Methoxy-4-(Trifluoromethyl)Pyridine-3-Carboxamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.