Description

6-(2,2,2-Trifluoroethoxy)Pyridine-3-Thiocarboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine core modified with a trifluoroethoxy group and a thiocarboxamide moiety. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine and sulfur-based functionalities into new molecular entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those requiring fluorinated pyridine scaffolds for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides where the trifluoroethoxy group can influence biological activity.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis or metal-organic frameworks (MOFs) due to the coordinating potential of the thiocarboxamide group.
• Material Science: Investigated as a monomer or additive for creating polymers with specific electronic or surface properties.
• Chemical Biology Probes: Employed in the design of molecular probes to study enzyme mechanisms or protein interactions.

Basic Information

Product Name	6-(2,2,2-Trifluoroethoxy)Pyridine-3-Thiocarboxamide
CAS No.	175277-59-5
Molecular Formula	C8H7F3N2OS
Molecular Weight	236.21 g/mol
Synonyms	6-(2,2,2-Trifluoroethoxy)nicotinothioamide; 3-Pyridinecarbothioamide, 6-(2,2,2-trifluoroethoxy)-; 6-(Trifluoroethoxy)pyridine-3-carbothioamide; 6-(2,2,2-Trifluoroethoxy)-3-pyridinecarbothioamide; 6-(2,2,2-Trifluoroethoxy)nicotinic acid thioamide; 6-(Trifluoroethoxy)nicotinothioamide; 175277-59-5; 6-(2,2,2-Trifluoroethoxy)pyridine-3-thiocarboxamide
EINECS	Contact for details

Quality Control

Our 6-(2,2,2-Trifluoroethoxy)Pyridine-3-Thiocarboxamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.