Description

Ethyl 4-Methyl-2-[5-(Trifluoromethyl)Pyrid-2-Yl]Thiazole-5-Carboxylate 97 is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure combining pyridine and thiazole rings with a trifluoromethyl group. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular modifications. It is primarily sought after by research institutions, custom synthesis firms, and pharmaceutical manufacturers engaged in the development of new chemical entities, agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Research: Serves as a core scaffold for developing new generation pesticides and herbicides, leveraging the biological activity of the thiazole and trifluoromethyl motifs.
• Chemical Biology & Proteomics: Used in the design and synthesis of molecular probes and enzyme inhibitors for biochemical pathway analysis and target validation.
• Material Science: Potential application in the synthesis of organic electronic materials and ligands for catalysis due to its electron-deficient aromatic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D pipelines.

Basic Information

Product Name	Ethyl 4-Methyl-2-[5-(Trifluoromethyl)Pyrid-2-Yl]Thiazole-5-Carboxylate 97
CAS No.	175277-54-0
Molecular Formula	C13H11F3N2O2S
Molecular Weight	316.30 g/mol
Synonyms	Ethyl 4-methyl-2-[5-(trifluoromethyl)-2-pyridyl]-1,3-thiazole-5-carboxylate; 2-(5-(Trifluoromethyl)pyridin-2-yl)-4-methylthiazole-5-carboxylic acid ethyl ester; 175277-54-0; 4-Methyl-2-(5-trifluoromethyl-2-pyridyl)thiazole-5-carboxylic acid ethyl ester; 5-Carbethoxy-4-methyl-2-[5-(trifluoromethyl)-2-pyridyl]thiazole; Thiazole-5-carboxylic acid, 4-methyl-2-[5-(trifluoromethyl)-2-pyridinyl]-, ethyl ester
EINECS	Contact for details

Quality Control

Our production of Ethyl 4-Methyl-2-[5-(Trifluoromethyl)Pyrid-2-Yl]Thiazole-5-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates, ensuring reliable supply and traceability for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.