Description

3-Chloro-5-(Trifluoromethyl)Pyridine-2-Carboxaldehyde is a high-purity, multi-functional heterocyclic building block of significant commercial importance. This compound is valued for its unique molecular scaffold, which combines a reactive aldehyde group with halogenated and fluorinated substituents, enabling precise chemical modifications. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl and chloro groups enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile starting material for creating novel pyridine-based ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethyl)Pyridine-2-Carboxaldehyde
CAS No.	175277-50-6
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	2-Formyl-3-chloro-5-(trifluoromethyl)pyridine; 3-Chloro-5-trifluoromethyl-2-pyridinecarboxaldehyde; 3-Chloro-5-(trifluoromethyl)picolinaldehyde; 3-Chloro-5-(trifluoromethyl)-2-pyridinecarbaldehyde; 2-Pyridinecarboxaldehyde, 3-chloro-5-(trifluoromethyl)-; 175277-50-6
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Trifluoromethyl)Pyridine-2-Carboxaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.