Description

5-Trifluoromethyl-Pyridine-2-Carboxamidine Hcl is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine-carboxamidine structure with a trifluoromethyl substituent. This compound is of significant commercial value for its role in the synthesis of bioactive molecules, particularly kinase inhibitors and other targeted therapeutics. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent kinase inhibitors and other small-molecule drug candidates.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging the biological activity of the pyridine-carboxamidine core.
• Chemical Biology & Proteomics: Serves as a versatile scaffold or precursor for activity-based probes and molecular tools targeting enzymatic activity.
• Material Science: Potential precursor for the synthesis of specialized ligands and functionalized polymers with unique electronic properties.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	5-Trifluoromethyl-Pyridine-2-Carboxamidine Hcl
CAS No.	175277-48-2
Molecular Formula	C7H7ClF3N3
Molecular Weight	225.60 g/mol
Synonyms	2-Carboxamidine-5-(trifluoromethyl)pyridine hydrochloride; 5-(Trifluoromethyl)pyridine-2-carboxamidine hydrochloride; 2-Pyridinecarboximidamide, 5-(trifluoromethyl)-, hydrochloride (1:1); 5-Trifluoromethyl-2-pyridinecarboxamidine HCl; 5-Trifluoromethylpicolinamidine hydrochloride
EINECS	Contact for details

Quality Control

Our production of 5-Trifluoromethyl-Pyridine-2-Carboxamidine Hcl adheres to stringent quality management protocols. Every batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to cGMP principles and regulatory compliance (including REACH) ensures a reliable supply for critical development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.