Description

2-Methoxy-5-(Trifluoromethyl)Pyridine is a versatile fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the electron-donating methoxy group and the electron-withdrawing trifluoromethyl group on the pyridine ring, which enables precise modulation of electronic and steric properties in target molecules. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced efficacy and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials requiring specific fluorine-containing motifs.
• Custom Synthesis and Contract Manufacturing: A high-value starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Methoxy-5-(Trifluoromethyl)Pyridine
CAS No.	175277-45-9
Molecular Formula	C7H6F3NO
Molecular Weight	177.12 g/mol
Synonyms	5-(Trifluoromethyl)-2-methoxypyridine; 2-Methoxy-5-(trifluoromethyl)pyridine; 2-Methoxy-5-trifluoromethylpyridine; 5-Trifluoromethyl-2-methoxypyridine; Pyridine, 2-methoxy-5-(trifluoromethyl)-; 175277-45-9
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and fluorinating agents. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.