Description

Methyl 2,5-Bis(2,2,2-Trifluoroethoxy)Benzoate is a high-purity fluorinated aromatic ester building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of the benzoate ester moiety with two trifluoroethoxy substituents, which impart enhanced lipophilicity, metabolic stability, and electronic properties to target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where fluorine incorporation is desired to modulate biological activity and physicochemical parameters.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the trifluoroethoxy groups can enhance bioavailability and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a fluorinated precursor in the production of specialty electronic chemicals for display and lighting technologies.
• Advanced Polymer Modification: Incorporated as a monomer or modifier to create fluorinated polymers with specific surface, thermal, or chemical resistance properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and other transformations to introduce complex, fluorinated aromatic systems.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	Methyl 2,5-Bis(2,2,2-Trifluoroethoxy)Benzoate
CAS No.	175204-89-4
Molecular Formula	C12H10F6O4
Molecular Weight	332.20 g/mol
Synonyms	Benzoic acid, 2,5-bis(2,2,2-trifluoroethoxy)-, methyl ester; Methyl 2,5-di(2,2,2-trifluoroethoxy)benzoate; 2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid methyl ester; Methyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate; 175204-89-4; Methyl 2,5-di(trifluoroethoxy)benzoate
EINECS	Contact for details

Quality Control

Our Methyl 2,5-Bis(2,2,2-Trifluoroethoxy)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.