Description

1,2,3,4-Tetrahydro-4-(Trifluoromethyl)Pyridine-5-Carboxamide is a high-value trifluoromethylated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and agrochemicals, where the introduction of the trifluoromethyl group can dramatically enhance metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the properties of the trifluoromethyl group.
• Advanced Material Precursor: Serves as a specialty monomer or additive in the development of performance polymers and liquid crystals.
• Chemical Biology Probe Development: Employed in medicinal chemistry for creating tool compounds and probes to study biological pathways and protein function.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of complex molecules.
• Custom Synthesis & Contract Manufacturing: A key starting material for fine chemical manufacturers offering bespoke synthesis services to the life science industry.

Basic Information

Product Name	1,2,3,4-Tetrahydro-4-(Trifluoromethyl)Pyridine-5-Carboxamide
CAS No.	175204-83-8
Molecular Formula	C7H9F3N2O
Molecular Weight	194.16 g/mol
Synonyms	4-(Trifluoromethyl)-1,2,3,4-tetrahydropyridine-5-carboxamide; 5-Carbamoyl-4-(trifluoromethyl)-1,2,3,4-tetrahydropyridine; 4-Trifluoromethyl-1,2,3,4-tetrahydropyridine-5-carboxylic acid amide; TFMP-Carboxamide (abbrev.); 175204-83-8; 4-(Trifluoromethyl)-5-pyridinecarboxamide, 1,2,3,4-tetrahydro-
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-4-(Trifluoromethyl)Pyridine-5-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.