Description

Ethyl 5-[3-(Dimethylamino)Prop-1-Ynyl]Nicotinate is a high-purity, advanced pharmaceutical intermediate featuring a unique nicotinate core functionalized with a dimethylamino-propyne side chain. This compound matters as a critical building block in the synthesis of complex molecules, particularly for research and development in medicinal chemistry. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel therapeutics, including potential kinase inhibitors and other targeted agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for investigational drugs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Used in organic synthesis to introduce the ethyl nicotinate moiety with an alkyne-linked tertiary amine functional group.
• Bioconjugation & Probe Development: The alkyne group enables click chemistry reactions, useful for creating fluorescent probes or bioconjugates for biochemical assays.
• Academic & Institutional R&D: Employed in university and research institute laboratories for exploratory synthetic chemistry and pharmacological studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the life sciences industry.

Basic Information

Product Name	Ethyl 5-[3-(Dimethylamino)Prop-1-Ynyl]Nicotinate
CAS No.	175203-71-1
Molecular Formula	C13H16N2O2
Molecular Weight	232.28 g/mol
Synonyms	Ethyl 5-(3-(Dimethylamino)prop-1-yn-1-yl)nicotinate; 5-[3-(Dimethylamino)prop-1-yn-1-yl]pyridine-3-carboxylic acid ethyl ester; Nicotinic acid, 5-[3-(dimethylamino)-1-propynyl]-, ethyl ester; Ethyl 5-(3-(dimethylamino)propynyl)nicotinate
EINECS	Contact for details

Quality Control

Our Ethyl 5-[3-(Dimethylamino)Prop-1-Ynyl]Nicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.