Description

Ethyl 5-(3-Hydroxyprop-1-ynyl)nicotinate is a high-purity, synthetically valuable nicotinate derivative featuring a terminal alkyne and a hydroxyl group, making it a versatile building block for advanced chemical synthesis. This compound is critical for researchers and manufacturers requiring precise molecular scaffolds for constructing complex heterocyclic systems and pharmaceutical intermediates. It is primarily utilized in the pharmaceutical, agrochemical, and advanced material research sectors for applications such as medicinal chemistry, ligand synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and neurology research.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization due to its modifiable alkyne and ester functionalities.
• Agrochemical Synthesis: Serves as a core structure for developing new active ingredients for crop protection.
• Chemical Biology Probes: The terminal alkyne group enables efficient conjugation via click chemistry for labeling and probing biological systems.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Advanced Material Research: Acts as a monomer or cross-linker in the development of functional polymers and smart materials.

Basic Information

Product Name	Ethyl 5-(3-Hydroxyprop-1-ynyl)nicotinate
CAS No.	175203-66-4
Molecular Formula	C11H11NO3
Molecular Weight	205.21 g/mol
Synonyms	5-(3-Hydroxy-1-propynyl)nicotinic acid ethyl ester; Ethyl 5-(3-hydroxypropynyl)nicotinate; Nicotinic acid, 5-(3-hydroxy-1-propyn-1-yl)-, ethyl ester; 3-Pyridinecarboxylic acid, 5-(3-hydroxy-1-propyn-1-yl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-(3-Hydroxyprop-1-ynyl)nicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.