Description

Methyl 4-Hydroxy-6-(Trifluoromethyl)Thieno[3,4-B]Pyridine-1-Carboxylate is a high-value, multi-functional heterocyclic building block characterized by its fused thienopyridine core and trifluoromethyl group. This compound is critical for advanced research and development, offering a unique scaffold for modulating the biological activity and physicochemical properties of target molecules. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in oncology, CNS disorders, and anti-infective therapies.
• Agrochemical Research: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the thienopyridine structure.
• Material Science Precursor: Serves as a specialized building block for creating advanced organic electronic materials and functional polymers.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a molecular probe in biochemical assays.
• Fluorine Chemistry: An essential reagent for introducing the trifluoromethyl group into complex molecular architectures, a common strategy in modern medicinal chemistry.

Basic Information

Product Name	Methyl 4-Hydroxy-6-(Trifluoromethyl)Thieno[3,4-B]Pyridine-1-Carboxylate
CAS No.	175203-39-1
Molecular Formula	C10H6F3NO3S
Molecular Weight	277.22 g/mol
Synonyms	Methyl 4-hydroxy-6-(trifluoromethyl)thieno[3,4-b]pyridine-1-carboxylate; 1-Carbomethoxy-4-hydroxy-6-trifluoromethylthieno[3,4-b]pyridine; 4-Hydroxy-6-(trifluoromethyl)thieno[3,4-b]pyridine-1-carboxylic acid methyl ester; Methyl 4-hydroxy-6-(trifluoromethyl)-1-thieno[3,4-b]pyridinecarboxylate; Thieno[3,4-b]pyridine-1-carboxylic acid, 4-hydroxy-6-(trifluoromethyl)-, methyl ester; 175203-39-1; 6-(Trifluoromethyl)-4-hydroxythieno[3,4-b]pyridine-1-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Hydroxy-6-(Trifluoromethyl)Thieno[3,4-B]Pyridine-1-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.