Description

n-[2-(Methylthio)Nicotinoyl]-L-Leucine is a specialized organic compound that serves as a key intermediate in advanced pharmaceutical synthesis and biochemical research. This molecule is valued for its unique structure, which combines a nicotinoyl moiety with a methylthio group and the amino acid L-leucine, enabling its use in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for applications in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug candidates and novel therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of enzyme inhibitors or receptor modulators.
• Peptidomimetic Synthesis: Serves as a component in the design and creation of peptide-like molecules with enhanced stability and bioavailability.
• Biochemical Probe Development: Utilized in the creation of labeled compounds or probes for studying biological pathways and mechanisms.
• High-Purity Reference Standard: Supplied as a certified reference material for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	n-[2-(Methylthio)Nicotinoyl]-L-Leucine
CAS No.	175201-69-1
Molecular Formula	C13H18N2O3S
Molecular Weight	282.36 g/mol
Synonyms	L-Leucine, N-[2-(methylthio)-3-pyridinecarbonyl]-; (S)-2-((2-(Methylthio)nicotinoyl)amino)-4-methylpentanoic acid; 2-(Methylsulfanyl)nicotinoyl-L-leucine; N-(2-Methylsulfanylpyridine-3-carbonyl)-L-leucine; 175201-69-1; Methylthionicotinoyl leucine; Leucine, N-[2-(methylthio)-3-pyridinecarbonyl]-, L-
EINECS	Contact for details

Quality Control

Our n-[2-(Methylthio)Nicotinoyl]-L-Leucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for pharmaceutical R&D and intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere if long-term stability is required. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-Isomer)
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.