Description

L-Proline, 4-Hydroxy-, 1-Methylethyl Ester, (4R)- (9Ci) is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a critical building block for the development of novel pharmaceuticals and bioactive molecules, particularly those targeting complex biological pathways. It is essential for research and manufacturing organizations in the pharmaceutical, biotechnology, and fine chemical sectors that require high-purity, stereochemically defined intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, enzyme modulators, and other active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used to construct constrained peptide analogs and peptidomimetics for drug discovery programs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions.
• Bioconjugation Chemistry: Useful for creating labeled probes or antibody-drug conjugates (ADCs) due to its functional handle.
• Agrochemical Development: A potential intermediate in the synthesis of advanced, biologically active crop protection agents.
• Academic & Industrial R&D: Serves as a standard or starting material for methodological development in organic and medicinal chemistry.

Basic Information

Item	Details
Product Name	L-Proline, 4-Hydroxy-, 1-Methylethyl Ester, (4R)- (9Ci)
CAS No.	175168-65-7
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	(4R)-4-Hydroxy-L-proline isopropyl ester; Isopropyl (4R)-4-hydroxy-L-prolinate; (2S,4R)-1-(1-Methylethyl) 4-hydroxy-2-pyrrolidinecarboxylate; 4-Hydroxy-L-proline isopropylester; L-Hydroxyproline isopropyl ester; (4R)-Hydroxy-L-proline isopropyl ester; trans-4-Hydroxy-L-proline isopropyl ester
EINECS	Contact for details

Quality Control

Our production of L-Proline, 4-Hydroxy-, 1-Methylethyl Ester, (4R)- (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.